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Introduction: Oral contraceptives OCs induce mood and libido changes. Main outcome measures: The main outcome measures are McCoy Female Sexuality Questionnaire MFSQ , the labia minora thickness and vaginal introitus area, the pulsatility index PI of clitoral and labia minora arteries, and hormonal and biochemical assays. The labia minora thickness was studied by two-dimensional ultrasonographic, and the clitoral and labia minora arteries were evaluated by color Doppler; three-dimensional static volumes of the vulvar area were calculated. Hormonal estradiol, androstenedione, and testosterone and biohumoral sex hormone binding globulin parameters were assayed. Results: After 3-month treatment, the labia minora thickness and the vaginal introitus area significantly decreased in comparison with the baseline values, whereas the PI of the dorsal clitoral artery and the posterior labial artery significantly increased.

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